Three times as many women have migraine as do men. That translates to 18% to 25% of women worldwide. A new study shows that this discrepancy might be because women’s brains are faster to activate the cascading waves of activity thought to cause migraine pain and other migraine symptoms.
The strength of the stimulus required to trigger these waves of activity, called cortical spreading depression (CSD), was two to three times higher for men than for women. This excitability indicates that women’s propensity toward migraine is linked to more than just menstrual cycle.